power-optimization-patterns
Direct and tradeoff-based optimization strategies for clinical trial design. Use when optimizing sample size, selecting design parameters, or performing sensitivity analysis.
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Direct and tradeoff-based optimization strategies for clinical trial design. Use when optimizing sample size, selecting design parameters, or performing sensitivity analysis.
Foundational knowledge for writing Stan 2.37 models including program structure, type system, distributions, and best practices. Use when creating or reviewing Stan models.
Survival analysis methods including weighted logrank, MaxCombo, RMST, and milestone tests. Use when analyzing TTE data or choosing analysis methods for non-proportional hazards.
Deep methodology knowledge for network meta-analysis including transitivity, consistency assessment, treatment rankings, and model selection. Use when conducting or reviewing NMA.
Patterns for hierarchical/multilevel Bayesian models including random effects, partial pooling, and centered vs non-centered parameterizations.
MCMC diagnostics for Bayesian models including convergence assessment, effective sample size, divergences, and posterior predictive checks.
Master tidy modelling patterns for ITC analyses following TMwR principles. Covers workflow structure, consistent interfaces, reproducibility best practices, and data validation. Use when setting up ITC analysis...
Bayesian meta-analysis models including fixed effects, random effects, and network meta-analysis with Stan and JAGS implementations.
Bayesian survival analysis models including exponential, Weibull, log-normal, and piecewise exponential hazard models with censoring support.
Deep methodology knowledge for ML-NMR including IPD/AgD integration, population adjustment, numerical integration, and prediction to target populations. Use when conducting or reviewing ML-NMR analyses.
Bayesian regression models including linear, logistic, Poisson, negative binomial, and robust regression with Stan and JAGS implementations.
Core Mediana package functions for Clinical Scenario Evaluation (CSE). Use when designing data models, analysis models, evaluation models, and running comprehensive trial simulations.
Foundational knowledge for writing PyMC 5 models including syntax, distributions, sampling, and ArviZ diagnostics. Use when creating or reviewing PyMC models.
Deep methodology knowledge for pairwise meta-analysis including fixed vs random effects, heterogeneity assessment, publication bias, and sensitivity analysis. Use when conducting or reviewing pairwise MA.
Group sequential design methods for interim analyses, alpha spending, and futility stopping. Use when designing trials with interim looks or implementing spending functions.
Deep methodology knowledge for STC including outcome regression approach, effect modifier selection, covariate centering, and comparison with MAIC. Use when conducting or reviewing STC analyses.
Respond directly to individual PR review comments using the GitHub API. Use when asked to reply to PR comments, address reviewer feedback, or communicate with reviewers on a PR.
Get today's date for web searches and date-sensitive tasks. Auto-invoke before any WebSearch that includes a year (e.g., "React 2024", "Python 2025"), when searching for current documentation, latest releases,...
Display rich content (markdown, code, diffs, mermaid diagrams) to users in a browser viewer. Use when you need to show complex content that benefits from rich rendering - reports, documentation, code with synta...
Consolidate multiple PR branches onto a target branch using jj multi-parent rebase with intelligent AI-powered conflict resolution
Automatically add standardized info banners to all new scripts and tools. Use when creating new PowerShell scripts, Bash scripts, or any executable tools in this repository.
Automatically create and update CHANGELOG.md files for scripts and tools following Keep a Changelog format. Use when creating new scripts, updating existing scripts, fixing bugs, or adding features to any tool...
Suggest commit messages based on staged changes and assist with committing using an editor.
Generate images using Google Gemini/Imagen API. Use when the user asks to create, generate, or make an image, picture, photo, illustration, artwork, or visual content.
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